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Unveiling the role of preceding seasonal influenza in the development of bacteremic pneumococcal pneumonia in older adults before the COVID-19 pandemic in Japan.
Int J Infect Dis
June 2024
Toyama Institute of Health, Toyama, Japan. Electronic address:
Article Synopsis
- The study investigated how seasonal influenza affects adults with invasive pneumococcal disease (IPD) in Japan, analyzing data from 1722 patients before and during the COVID-19 pandemic.
- It found that the seasonal influenza epidemic declined with the pandemic, and there was a notable decrease in bacteremic pneumonia cases during this time.
- Additionally, patients with a history of seasonal influenza had a higher rate of bacteremic pneumonia and a greater risk of death, especially among older males, prior to the pandemic.
Sequential Treatment Failure With Aztreonam-Ceftazidime-Avibactam Followed by Cefiderocol Due to Preexisting and Acquired Mechanisms in a New Delhi Metallo-β-lactamase-Producing Escherichia coli Causing Fatal Bloodstream Infection.
Clin Infect Dis
June 2024
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
We report a fatal case of New Delhi metallo-β-lactamase (NDM)-producing Escherichia coli in a bacteremic patient with sequential failure of aztreonam plus ceftazidime-avibactam followed by cefiderocol. Acquired resistance was documented phenotypically and mediated through preexisting and acquired mutations. This case highlights the need to rethink optimal treatment for NDM-producing organisms.
View Article and Find Full Text PDFThe Etiology, Antibiotic Therapy and Outcomes of Bacteremic Skin and Soft-Tissue Infections in Onco-Hematological Patients.
Antibiotics (Basel)
December 2023
Infectious Diseases Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Objectives: to assess the current epidemiology, antibiotic therapy and outcomes of onco- hematological patients with bacteremic skin and soft-tissue infections (SSTIs), and to identify the risk factors for Gram-negative bacilli (GNB) infection and for early and overall mortality.
Methods: episodes of bacteremic SSTIs occurring in cancer patients at two hospitals were prospectively recorded and retrospectively analyzed.
Results: Of 164 episodes of bacteremic SSTIs, 53% occurred in patients with solid tumors and 47% with hematological malignancies.
Invasive and Non-Invasive Human Salmonellosis Cases Admitted between 2015 and 2021 in Four Suburban Hospitals in the Metropolitan Area of Milan (Italy): A Multi-Center Retrospective Study.
Pathogens
October 2023
UOC Malattie Infettive, ASST Ovest-Milanese, Ospedale Nuovo di Legnano, Via Papa Giovanni II s.n., Legnano, 20025 Milano, Italy.
Article Synopsis
- Non-Typhoidal Salmonellas (NTSs) are widely prevalent in Italy, with over 3,500 cases reported annually, but there is limited data on salmonellosis.
- A study involving 252 patients revealed that extreme ages were significantly associated with bacteremic infections, with invasive infections exhibiting a much higher mortality rate.
- The study also noted a rising trend in antibiotic resistance, particularly to common antibiotics, and highlighted diarrhea and fever as the most frequent symptoms, emphasizing the serious impact of NTS infections on vulnerable populations.
Range of Clinical Manifestations Caused by Invasive Meningococcal Disease Due to Serogroup W: A Systematic Review.
Infect Dis Ther
October 2023
Institut Pasteur, Université Paris Cité, Invasive Bacterial Infections, National Reference Centre for Meningococci and Haemophilus Influenzae, 25-28 Rue du Dr Roux, 75015, Paris, France.
Introduction: Invasive meningococcal disease (IMD) due to serogroup W meningococci (MenW) is consistently reported with atypical clinical manifestations, including gastrointestinal symptoms, bacteremic pneumonia, and septic arthritis. We undertook a systematic review of the literature for a comprehensive assessment of the clinical presentation of IMD caused by MenW.
Methods: PubMed and Embase databases were searched from inception to June 2022 using a combination of MeSH terms and free text for articles that reported symptoms and signs of MenW IMD, and associated manifestations.
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