Acute mountain sickness (AMS) is a frequent complication for military personnel, veterans, athletes, and travelers at high altitudes. Symptoms may occur in individuals with less cerebrospinal fluid volume and less ability to accommodate increased brain volume. No studies on AMS exist in individuals with neurological impairments. We studied 64 subjects, including active and sedentary controls and those with tetraplegia, paraplegia, multiple sclerosis, and traumatic brain injury at the 2007 National Veterans Winter Sports Clinic in Snowmass, Colorado. Subjects completed three Lake Louise Score surveys to quantify symptoms. We found a higher than expected occurrence of AMS overall (51.6%) but no differences among groups, and few participants sought treatment. Fatigue and weakness were common symptoms. High subject activity levels may explain these findings. More research is warranted on larger sample sizes and on preventative medications and treatments for AMS, especially since many military personnel with neurological impairments are returning to full active service.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1682/jrrd.2007.08.0136 | DOI Listing |
Sports (Basel)
December 2024
Department of Physical Education and Health in Biala Podlaska, Faculty in Biała Podlaska, Jozef Pilsudski University of Physical Education, 00-968 Warsaw, Poland.
Frequent changes in altitude and oxygen levels limit the practical application of traditionally derived exercise thresholds or training zones based on heart rate (HR) or blood lactate concentration (bLa). We investigated the transferability of a muscle oxygenation (SmO)-based intensity prescription between different hypoxic conditions to assess the suitability of real-time SmO measurements for ski-mountaineering (SKIMO) athletes during submaximal endurance exercise. A group of 15 well-trained male SKIMO athletes performed a graded-intensity run test in normoxia (87 m ASL, FiO = 20.
View Article and Find Full Text PDFOrthop Rev (Pavia)
December 2024
Anesthesiology Montefiore Medical Center, Albert Einstein College of Medicine.
Introduction: Opioid use disorder is a chronic illness with significant morbidity and mortality. Opioid agonists, like buprenorphine, are commonly used to prevent relapse. Recent changes in buprenorphine legislation are expected to increase prescription and guidelines recommend its continuation during the perioperative period for many patients.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
International Vaccine Institute, Seoul, Republic of Korea.
Background: Hepatitis E virus (HEV) causes acute jaundice and poses an important public health problem in low- and middle-income countries. Limited surveillance capacity and suboptimal access to diagnostics leads to under-reporting of HEV infections in affected countries, including Nepal. Serum antibodies against HEV are indicative of past infection.
View Article and Find Full Text PDFDigit Health
December 2024
Department of Sport Science, University of Innsbruck, Innsbruck, Austria.
We read with interest the paper on "Smartwatch measurement of blood oxygen saturation for predicting acute mountain sickness: Diagnostic accuracy and reliability" recently published by Zeng and colleagues in Digital Health. This study demonstrated good reliability and high precision for measuring peripheral oxygen saturation (SpO) using Huawei smartwatches during a 1-wk high altitude exposure. In addition, SpO values recorded during the ascent to high altitude were predictive for the development of acute mountain sickness (AMS).
View Article and Find Full Text PDFBlood Adv
December 2024
City of Hope, Duarte, California, United States.
The anti-apoptotic protein myeloid cell leukemia-1 (Mcl-1) contributes to the pathophysiology of acute myeloid leukemia (AML) and certain B-cell malignancies. Tumor dependence on Mcl-1 is associated with resistance to venetoclax. Voruciclib, an oral cyclin-dependent kinase (CDK) inhibitor targeting CDK9, indirectly decreases Mcl-1 protein expression and synergizes with venetoclax in preclinical models.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!