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Haploidentical transplantation with post-transplant cyclophosphamide versus single cord blood transplantation in adults with relapsed/refractory non-Hodgkin lymphoma.
Bone Marrow Transplant
December 2024
Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Article Synopsis
- * A study using data from the Japanese nationwide transplantation registry assessed 857 patients with relapsed or refractory non-Hodgkin lymphoma, with 169 receiving PTCY-haplo and 688 receiving uCBT, revealing no significant differences in overall survival, progression-free survival, or graft-versus-host disease-free/relapse-free survival between the two groups.
Fludarabine Melphalan, Reduced-dose Busulfan Versus Fludarabine, Melphalan, Full-dose Busulfan in Patients Receiving Cord Blood Transplantation.
Transplant Proc
October 2024
Department of Medicine, Division of Hematology, Showa University School of Medicine, Shinagawa-Ku, Tokyo, Japan. Electronic address:
Article Synopsis
- This study compares two chemotherapy regimens used in patients undergoing umbilical cord blood transplantation: Flu/Mel/Bu2 (lower busulfan dose) and Flu/Mel/Bu4 (higher busulfan dose).
- Researchers analyzed data from 87 adult patients to see if there were differences in nonrelapse mortality, relapse rates, progression-free survival, and overall survival between the two regimens.
- The results showed no significant differences in outcomes, suggesting that the Flu/Mel/Bu2 regimen is a safe and effective option, particularly for older patients.
Impact of Race and Ethnicity on Outcomes After Umbilical Cord Blood Transplantation.
Transplant Cell Ther
October 2024
CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Article Synopsis
- - The study investigates the survival outcomes of patients receiving umbilical cord blood transplants (UCBT) across different racial and ethnic groups, focusing on Black, Latinx, White, and Asian patients, as previous research indicated disparities in survival rates.
- - A retrospective analysis of data from the Center for International Blood and Marrow Transplant Research (CIBMTR) included 983 single and 1529 double UCBT recipients, measuring outcomes like overall survival (OS), disease-free survival, and transplant-related mortality over two years.
- - Results showed that while overall survival rates varied by race/ethnicity, with Latinx patients having significantly lower OS compared to Blacks, no significant differences were observed in child patients,
Unrelated umbilical cord blood transplantation with low-dose anti-thymocyte globulin for children with severe aplastic anemia: A case series.
Ann Hematol
June 2024
Department of Hematology, Children's Hospital Capital Institute of Pediatrics, Beijing, 100020, China.
Objective: This study aimed to investigate the prognosis of unrelated umbilical cord blood transplantation (UCBT) using low-dose anti-thymocyte globulin (ATG) in children diagnosed with severe aplastic anemia (SAA).
Methods: This retrospective case series study was conducted involving pediatric SAA patients treated at the Capital Institute of Pediatrics from January 2020 to February 2023. All patients underwent a reduced-intensity conditioning (RIC) regimen alongside low-dose ATG.
[Single non-blood-related umbilical cord blood transplantation using a reduced-intensity conditioning regimen for the treatment of severe aplastic anemia].
Zhonghua Xue Ye Xue Za Zhi
January 2024
Department of Hematology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China Anhui Provincial Key Laboratory of Blood Research and Applications, Hefei 230001, China Blood and Cell Therapy Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
To evaluated the clinical efficacy of a reduced-intensity preconditioning regimen for single non-blood-related umbilical cord blood transplantation (sUCBT) in the treatment of severe aplastic anemia (SAA) . The clinical data of 63 patients with SAA who underwent sUCBT from January 2021 to July 2023 at the Department of Hematology of the First Affiliated Hospital of USTC were retrospectively analyzed. Fifty-two patients received total body irradiation/total bone marrow irradiation (TMI) combined with fludarabine or a cyclophosphamide- conditioning regimen (non-rATG group) , while 11 patients received rabbit anti-human thymocyte immunoglobulin (rATG) combined with TMI, fludarabine, or the cyclophosphamide-conditioning regimen (rATG group) .
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