Significant role of immune inflammatory reactions along with activation of the RAAS (rennin-angiotensin-aldosterone system) and the sympatho-adrenal system in CHF (chronic heart failure) pathogenesis is considered in the present survey article. Together with haemodynamic disorders activation of inflammatory reactions, which involve anti-inflammatory cytokines, is shown to be one of the main factors affecting CHF course and prognosis. Alteration of cytokine level is associated with injury level, gravity of the disease course and its clinical outcome. Prognostic value of determination of inflammation mediators as predictors of cardiovascular diseases and clinical outcomes is evaluated. Urgency of search for new medication in addition to "traditional preparations" used for the treatment of CHF is shown.
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