Yokuininto was effective in treating burning pain in both lower legs of a 58-year-old woman. She felt her lower legs feverish: however, no neurological deficit or abnormal finding in angiography was found. The burning pain was increased by cold and decreased by warm, but was alleviated by epidural block with local anesthetics. After 2-week medication of Yokuininto, burning pain was reduced to 20 to 30% and fever in legs disappeared. Yokuininto has been used for chronic pain in muscle and joint accompanied by swelling or local fever. This patient had no joint pain or swelling, but her burning pain was considered to have resulted from some abnormality in blood circulation due to disorder in discharge of water in the body.

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