AI Article Synopsis
- The study aimed to demonstrate the effectiveness of dual-time-point imaging using 18F-FDG-PET for better identification of liver tumors by analyzing changes in the tumor-to-background ratio.
- In a group of 34 patients with 90 confirmed liver metastases, the second delayed scan detected 90% of lesions compared to only 59% in the first scan, showing a significant improvement in diagnosis (p<0.001).
- Results indicated that while the second scan increased the detection of liver lesions and improved the tumor-to-background ratio, about 10% of malignant lesions were still missed with this imaging technique.
Article Abstract
Purpose: To prove the sensitivity of dual-time-point imaging with 18F-flourodeoxyglucose-positron emission tomography (18F-FDG-PET) of the liver to evaluate possible changes in the tumor-to-background ratio considering an improved detection rate of liver lesions.
Procedures: Image acquisition for the first whole-body scan started at a mean time point of 69 min (55-110 min). The mean time interval between the injection of 18F-FDG and the second delayed scan was 100 min (85-166 min).
Results: Of 90 proven liver metastases in 34 patients, the first scan detected 53 (59%) liver lesions correctly, whereas in the second, delayed scan 81 (90%) lesions were diagnosed correctly (p<0.001). The mean Standardized uptake values in the first and second delayed scan were 6.59 g/ml versus 8.09 g/ml, respectively (p<0.001). Tumor-to-background ratio of the first and second delayed scan were 2.0 and 2.7, respectively (p=0.04).
Conclusions: Dual-time-point-imaging of the liver showed a significant increase of tumor-to-background ratio and hypermetabolic lesion diameter. Although, 30% of all verified liver lesions could only be detected in the second delayed scan 10% of all malignant liver lesions were missed with FDG-PET.
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| http://dx.doi.org/10.1007/s11307-008-0159-y | DOI Listing |
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