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Drug Development.
Alzheimers Dement
December 2024
Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Background: Cognitive impairment, a common aging-related pathology, is a risk factor for dementia. Echinacoside (ECH), derived from the traditional Chinese medicine Cistanche deserticola, shows anti-aging properties including anti-inflammation, oxidative stress reduction, and neuronal protection. Despite its benefits, the beneficial impact of ECH on age-related cognitive decline remains unclear.
View Article and Find Full Text PDF[Diagnostic tools for stroke detection-from prehospital to diagnosis].
Med Klin Intensivmed Notfmed
January 2025
Neurologische Klinik des Universitätsklinikums Gießen, Klinikstraße 33, 35392, Gießen, Deutschland.
Background: Strokes are common neurological emergencies that require rapid diagnosis to minimize long-term damage. Prehospital detection and triage play a critical role in patient outcomes.
Objective: How effective are different prehospital diagnostic tools for stroke detection, and which triage strategies optimize patient care?
Methods: The article compares prehospital diagnostic tools for stroke detection and evaluates different transport strategies.
Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma.
Mol Clin Oncol
February 2025
Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan.
Currently, neoadjuvant chemotherapy (NAC) is usually performed even for resectable pancreatic ductal adenocarcinoma (rPDAC). The present study investigated the benefits of NAC with gemcitabine plus S-1 for rPDAC. The medical records of 170 patients diagnosed as having rPDAC based on preoperative imaging were reviewed retrospectively.
View Article and Find Full Text PDFHeat Treatment as a Safe-Handling Procedure for Rift Valley Fever Virus.
Pathogens
December 2024
Laboratory of Virology, National Institute for Infectious Disease "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.
Rift Valley Fever virus (RVFV) is a mosquito-borne virus with high pathogenic potential in ruminants and humans. Due to its high potential for spreading, it is considered a priority pathogen, and it is included in the Bluepoint list of the World Health Organization (WHO). Given the high pathogenic potential of the virus, it is crucial to develop a rapid heat-mediated inactivation protocol to create a safer working environment, particularly in medical facilities that lack a biosafety level 3 laboratory required for direct handling of RVFV.
View Article and Find Full Text PDFNovel Isoxazole-Based Antifungal Drug Candidates.
Int J Mol Sci
December 2024
Department of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Microbiological communities have a significant impact on health and disease. are ubiquitous fungal pathogens that colonize the mucosal surfaces of the genital, urinary, respiratory, and gastrointestinal tracts, as well as the oral cavity. If the immune system is inadequate, then infections may pose a significant threat.
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