We discuss a generalized waveplate hinge model to characterize anisotropic effects associated with the hinge model of polarization-mode dispersion in installed systems. In this model, the action of the hinges is a random time-dependent rotation about a fixed axis. We obtain the probability density function of the differential group delay and the outage probability of an individual wavelength band using a combination of importance sampling and the cross-entropy method, and we then compute the noncompliant capacity ratio by averaging over wavelength bands. The results show that there are significant differences between the outage statistics predicted by isotropic and anisotropic hinge models.
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http://dx.doi.org/10.1364/ol.33.001924 | DOI Listing |
Bioorg Chem
January 2025
Center for Preclinical Safety Evaluation of Drugs, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:
In this study, we reported the discovery of a novel type II c-Met/Axl inhibitor, characterized by using 4-amino-7H-pyrrolo[2,3-d]pyrimidine as a hinge region binder. Through a systematic exploration of the structure-activity relationship, based on the clinically reported c-Met inhibitor BMS-777607, we identified the optimized compound 22a. 22a exhibited remarkable potency against c-Met and Axl kinases, with IC values of 1 nM and 10 nM, respectively, and demonstrated over 100-fold selectivity to other members of the TAM subfamily.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Smart Forming Process Group, Korea Institute of Industrial Technology, Ulsan 44776, Republic of Korea.
For allowable defect analyses, the fracture toughness of materials needs to be accurately predicted. In this regard, a lower fluctuation of fracture toughness can lead to reduction in safety and economic risks. Crack tip opening displacement (CTOD), which is the representative parameter for fracture toughness, can be measured by various methods, such as the δ5, the J-conversion method, the single clip gauge method, and the double clip gauge method.
View Article and Find Full Text PDFHeliyon
January 2025
School of Human Movement and Nutrition Science, The University of Queensland, Brisbane, Australia.
The human ankle joint complex, consisting of calcaneus, talus, and tibia, is often simplified as a single functional ankle joint, neglecting the motion of the talus. Understanding the individual contributions of the talus and calcaneus is crucial for comprehending ankle joint complex function in healthy populations, and alterations in function that may exist in clinical conditions. To achieve accurate bone kinematics, high-resolution biplanar videoradiography was used with participants engaged in walking and running (n = 9) and hopping (n = 9) with no overlap in participants.
View Article and Find Full Text PDFSci Rep
January 2025
School of Emergency Management and Safety Engineering, China University of Mining & Technology, Beijing, 100083, China.
To address limitations of traditional inclinometers and height sensors in determining the posture and support height of hydraulic supports in coal mining, we propose a novel method predicated on travel measurements of the leg and tail beam cylinders. This method calculates the posture and height of hydraulic supports in mechanized mining. By conducting meticulous kinematic analysis of the hydraulic supports, a skeleton model of the main structural parameters of the hydraulic support was constructed.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2025
Physics Department, College of Science, King Faisal University, Al Ahsa, 31982, Saudi Arabia. Electronic address:
To consistently determine the anomalous characteristics of phthalic acid crystal (PAC) derivatives, we performed quantum dynamics simulations of the infrared spectral density of the h-PAC and d-PAC isotopomers that show up in the H/D isotopic frequency domain at two different temperatures viz. 77 and 298 K. A theoretical framework explaining the dynamical cooperative interactions within the hydrogen bonds (HBs) in the PAC crystals across a simulation of IR spectral density of the stretching band was developed.
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