Transcription in eukaryotes is regulated by many enzymes that influence the nuclear organization of DNA in chromatin. Several of these enzymes regulate histone modifications. These modifications function as a platform for assembly of protein complexes that influence chromatin structure. Dynamic changes between chromatin states that facilitate or inhibit transcription are important in the transcriptional regulation of pathways controlling floral induction in response to environmental and developmental signals. This review focuses on the mechanistic aspects of histone modifications and chromatin changes at flowering-time genes and how these relate to the initiation of flowering.
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http://dx.doi.org/10.1016/j.semcdb.2008.07.015 | DOI Listing |
Curr Med Chem
January 2025
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Histone deacetylases (HDACs) play a crucial role in the regulation of cancer progression and have emerged as key targets for antitumor therapy. Histone Deacetylase Inhibitors (HDACis) effectively suppress tumor cell proliferation, induce apoptosis, and cause cell cycle arrest, demonstrating broad-spectrum antitumor activity. This article primarily focuses on enhancing the selectivity of HDACis through structural modification using natural compounds.
View Article and Find Full Text PDFCell Commun Signal
January 2025
School of Basic Medical Sciences, Hubei University of Science and Technology, Hubei, 437000, China.
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses.
View Article and Find Full Text PDFMicrob Pathog
January 2025
Cell Biology and Molecular Genetics, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, INDIA. Electronic address:
Fungal hybrids arise through the interbreeding of distinct species. This hybridization process fosters increased genetic diversity and the emergence of new traits. Mechanisms driving hybridization include the loss of heterozygosity, copy number variations, and horizontal gene transfer.
View Article and Find Full Text PDFTranscription introduces torsional stress in the DNA fiber causing it to transition from a relaxed to a supercoiled state that can propagate across several kilobases and modulate the binding and activity of DNA-associated proteins. As a result, transcription at one locus has the potential to impact nearby transcription events. In this study, we asked how DNA supercoiling affects histone modifications and transcription of neighboring genes in the multicellular eukaryote .
View Article and Find Full Text PDFGene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibility and histone modifications. These complex networks have been shown to be disrupted during aging, disease, and cancer. However, profiling these networks across diverse cell types and states has been limited due to the technical constraints of existing methods for mapping DNA:Protein interactions in single cells.
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