Infants with severe cardiorespiratory failure treated with extracorporeal membrane oxygenation are at risk of hypoxic-ischemic injury and infarction of the brain, intracranial hemorrhage, and seizures. Consequently, this can lead to adverse neurodevelopmental outcome. We present a neonate treated with veno-arterial extracorporeal membrane oxygenation due to diaphragmatic hernia. The infant's brain function was continuously monitored with amplitude-integrated electroencephalography. The child experienced clinical seizures and subclinical seizure discharges, detected by amplitude-integrated electroencephalography, permitting the opportunity to treat them and adjust the anticonvulsive treatment accordingly.
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Article Synopsis
- Amplitude-integrated electroencephalogram (aEEG) is a tool for continuous monitoring of brain function in preterm infants and may help predict their neurodevelopmental outcomes.
- A systematic review of 19 studies involving 2074 preterm neonates showed that specific aEEG patterns, such as burst suppression and low voltage backgrounds, are linked to poorer outcomes, while normal backgrounds predict better development.
- Early monitoring of aEEG, particularly within the first week of life, is crucial for accurately assessing the neurodevelopmental prognosis of preterm infants.
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