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Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts.
Am J Pathol
September 2024
Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida. Electronic address:
Chorioamnionitis generates prostaglandin (PG) E and F, promoting fetal membrane rupture, cervical ripening, and uterine contractions. 15-Hydroxyprostaglandin dehydrogenase (HPGD) contributes to pregnancy maintenance by inactivating PGs. Herein, the role of decidual cells in the regulation of HPGD expression at the maternal-fetal interface was investigated.
View Article and Find Full Text PDFTranscriptional landscape of human trophoblast cells treated with calcitriol and TGF-β1.
Mol Cell Endocrinol
January 2024
Departamento de Biología de la Reproducción "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, Ciudad de México, 14080, Mexico. Electronic address:
Calcitriol and transforming growth factor beta 1 (TGF-β1) are unrelated molecules that regulate biological processes according to the genetic target, cell type, and context. Several studies have shown independent effects of calcitriol and TGF-βs on the placenta, but there is no information regarding the impact of their combination on these cells. Therefore, this study analyzed the effects of calcitriol, TGF-β1, and their combination in primary cultures of human trophoblast cells using a whole genome expression microarray.
View Article and Find Full Text PDFThe Enzyme 15-Hydroxyprostaglandin Dehydrogenase Inhibits a Shift to the Mesenchymal Pattern of Trophoblasts and Decidual Stromal Cells Accompanied by Prostaglandin Transporter in Preeclampsia.
Int J Mol Sci
March 2023
Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Preeclampsia (PE) is a pregnancy complication beginning after 20 weeks of pregnancy that involves high blood pressure (systolic > 140 mmHg or diastolic > 90 mmHg), with or without proteinuria. Insufficient trophoblast invasion and abnormal decidualization are involved in PE development. However, whether unhealthy placenta and decidua have the same biological activities is unclear.
View Article and Find Full Text PDFInvestigations on the potential role of prostaglandin E2 in canine uterine inertia.
Theriogenology
November 2021
Reproductive Unit of the Clinics - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Department of Veterinary Clinical Sciences, Section of Veterinary Reproduction and Obstetrics, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Prostaglandin (PG) E2 plays a crucial role in the endocrine network of canine parturition and we hypothesized that PGE2, 15-hydroxyprostaglandin dehydrogenase (HPGD) and PG-transporter (PGT) might be involved in the development of primary uterine inertia (PUI). We investigated PTGE synthase (PTGES), PTGE receptors 2/4 (PTGER2/4), HPGD and PGT expression on the mRNA- and protein-level in interplacental (IP) and uteroplacental (UP) tissues of bitches presented with dystocia undergoing emergency caesarean section. Groups were formed retrospectively based on strict criteria: PUI (n = 12; small/normal/large litter - PUI-S/N/L: n = 5/4/3), and obstructive dystocia (OD, n = 8).
View Article and Find Full Text PDFUterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes.
Prostaglandins Other Lipid Mediat
January 2017
Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland. Electronic address:
15-Hydroxyprostaglandin dehydrogenase (HPGD) plays a key role in prostaglandins (PGs) catabolism. Its expression and activity appear to be regulated by progesterone (P4). We investigated the HPGD mRNA-expression and protein localization in placentomes and interplacental uterine sites throughout gestation (Study I), and after fetal membranes retention (RFM) compared with normally delivered fetal membranes (DFM) (Study II).
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