AI Article Synopsis
- The study investigates how the Rep protein from Mungbean yellow mosaic India virus (MYMIV) interacts with viral DNA replication origins, specifically binding to iterons, which may be crucial for starting DNA replication.
- MYMIV Rep also functions as a helicase after replication initiation and its activity increases when interacting with the RPA32 subunit of Replication Protein A.
- The findings provide insights into the mechanisms of both the initiation and elongation phases of MYMIV DNA replication, highlighting the importance of these proteins in the replication process.
Article Abstract
In order to explore the mechanism of geminivirus DNA replication, we show that the Replication initiator (Rep) protein encoded by Mungbean yellow mosaic India virus (MYMIV), a member of the family Geminiviridae, binds specifically to the iterons present in the viral DNA replication origin (CR-A) in a highly ordered manner that might be a prerequisite for the initiation of replication. MYMIV Rep also acts as a helicase during the post-initiation stage and is upregulated in presence of the RPA32 subunit of Replication Protein A. The implication of these findings on the initiation and elongation stages of MYMIV DNA replication has been discussed.
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| http://dx.doi.org/10.1016/j.virol.2008.07.010 | DOI Listing |
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