AI Article Synopsis
- Two distinct populations of thymocytes, immature and mature, were identified by their rosette characteristics.
- The immature thymocytes could spontaneously mature but were inhibited by high levels of thymic hormone in the thymus.
- Upon emigration to peripheral organs, these cells had a higher proportion of small rosettes and were influenced by lower thymic hormone levels, which facilitated their maturation.
Article Abstract
The data indicated that 2 populations of thymocytes existed: immature and mature types, identifiable by their rosette characters. The immature type was capable of changing spontaneously to the mature type, but was partially suppressed in vivo by the high concentration of thymic hormone present in the intrathymic environment. The mature types of thymocytes emigrated to the peripheral organ, accounting for their high percentage of small rosettes. Alternately, cells of peripheral organs might have originated from the immature type in the thymus. Once emigrated and exposed to a lower concentration of thymic hormone, they changed into the mature pattern. The fact that lymph node rosettes were less affected by culture in vitro indicated that once cells have changed to the mature pattern they have less ground for further differentiation.
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| http://dx.doi.org/10.1007/978-1-4684-3300-5_11 | DOI Listing |
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