The diffuse infiltrative nature of cerebral glioma is a primary reason for failure of current treatment regimes. An improved understanding of the molecular determinants of tumour invasion is imperative in order to achieve therapeutic advances. Integrin-linked kinase has been shown to be key in the regulation of cell migration, as well as proliferation and apoptosis. The involvement of integrin-linked kinase in glioma biology, and its potential as a possible therapeutic target, is discussed.
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| http://dx.doi.org/10.1016/j.jocn.2008.01.008 | DOI Listing |
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