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File: /var/www/html/index.php
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File: /var/www/html/application/controllers/Detail.php
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Severity: Warning
Message: Trying to access array offset on value of type null
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
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Severity: Warning
Message: Trying to access array offset on value of type null
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File: /var/www/html/application/controllers/Detail.php
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File: /var/www/html/application/models/Detail_model.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Severity: 8192
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Filename: helpers/my_audit_helper.php
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Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Line Number: 256
Backtrace:
File: /var/www/html/application/controllers/Detail.php
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Message: Trying to access array offset on value of type null
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Message: Trying to access array offset on value of type null
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File: /var/www/html/application/controllers/Detail.php
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Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. | LitMetric
Beta-site APP cleaving enzyme-1 (BACE-1), is a rate-limiting enzyme for beta amyloid production. Beta amyloid induces the production of radical oxygen species and neuronal injury. Oxidative stress plays a key role in various neurological diseases such as ischemia and Alzheimer's disease. Recent studies suggest that oxidative stress induces BACE-1 protein upregulation in neuronal cells. Here, we demonstrate that naturally occurring compounds (-)-epigallocatechin-3-gallate and curcumin suppress beta amyloid-induced BACE-1 upregulation. Exposure of beta amyloid 1-42 to neuronal culture increased BACE-1 protein levels. (-)-Epigallocatechin-3-gallate or curcumin significantly attenuated beta amyloid-induced radical oxygen species production and beta-sheet structure formation. These two compounds have novel pharmacological effects that may be beneficial for Alzheimer's disease treatment.
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