Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573095 | PMC |
| http://dx.doi.org/10.1128/AAC.00196-08 | DOI Listing |
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