We evaluated the accuracy of diagnostic codes for schizophrenia in identifying actual cases in the historical charts of 801 primary care patients. The rate of schizophrenia by diagnostic code was 14%, whereas the estimated rate based on independent clinical chart review by a trained psychiatrist, using DSM-IV criteria, was 1.8%. The findings suggest that coded data alone should not be used to determine which patients have schizophrenia for research studies.

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