To solve the problem of imprecise positioning of feature point and of the feature data redundancy in facial expression recognition by active appearance models (AAM), the automatic adjustment of initial model for AAM fitting is proposed in this paper. The specific aims are to improve the precision of positioning and to more effectively reflect the variation of expressions by acquired features. The problem of feature selection is resolved by adopting quadratic mutual information and reducing the feature dimension. The support vector machine (SVM) classifier is used for expression recognition. The experimental results on CAS-PEAL facial expression database show that the proposed method effectively improves the performance of facial expression recognition, the maximum recognition rate being 83.33%.
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Brain Struct Funct
January 2025
Laboratoire de Neurosciences Cognitives et Adaptatives, Université de Strasbourg, 67000, Strasbourg, France.
This mini-review explores sexual dimorphism in the ventral midline thalamus, focusing on the reuniens nucleus and its role in behavioral functions. Traditionally linked to tasks such as working memory, cognitive flexibility, fear generalization, and memory consolidation, most studies have been conducted in male rodents. Research comparing the effects of ventral midline thalamus manipulations between female and male rodents is limited.
View Article and Find Full Text PDFiScience
November 2024
Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Methyltransferase-like 3 (METTL3), the core methyltransferase for -methyladenosine (m6A), plays a crucial role in innate immunity by introducing m6A modifications on viral or host RNAs. Despite its well-established catalytic function in m6A deposition, the broader role of METTL3 in immune regulation remains unclear. Here, we uncovered that EV71 infection enhanced METTL3 expression in interferon (IFN)-deficient Vero and IFN-proficient rhabdomyosarcoma (RD) cells by modulating transcription and post-translational modification, respectively.
View Article and Find Full Text PDFACS Omega
December 2024
Division of Solid-State Electronics, Department of Electrical Engineering, The Ångström Laboratory, Uppsala University, SE-751 03 Uppsala, Sweden.
Extracellular vesicles (EVs) are nanoparticles encapsulated with a lipid bilayer, and they constitute an excellent source of biomarkers for multiple diseases. However, the heterogeneity in their molecular compositions constitutes a major challenge for their recognition and profiling, thereby limiting their application as an effective biomarker. A single-EV analysis technique is crucial to both the discovery and the detection of EV subpopulations that carry disease-specific signatures.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Respiratory Medicine, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Xinghualing Area, 030000, Taiyuan, China.
Objectives: N7-methylguanosine (m7G) modification is closely related to the occurrence of human diseases, but its roles in sepsis remain unclear. This study aimed to explore the patterns of lethality-related m7G regulatory factor-mediated RNA methylation modification and immune microenvironment regulatory features in sepsis.
Methods: Three sepsis-related datasets (E-MTAB-4421 and E-MTAB-4451 as training sets and GSE185263 as a validation set) were collected, and differentially expressed m7G-related genes were analyzed between survivors and non-survivors.
Curr Alzheimer Res
December 2024
Neck-Pain Hospital of Shoulder and Lumbocrural Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Unlabelled:
Introduction: Alzheimer's disease (AD) represents the most common neurodegenerative disorder, characterized by progressive cognitive decline and memory loss. Despite the recognition of mitochondrial dysfunction as a critical factor in the pathogenesis of AD, the specific molecular mechanisms remain largely undefined.
Method: This study aimed to identify novel biomarkers and therapeutic strategies associated with mitochondrial dysfunction in AD by employing bioinformatics combined with machine learning methodologies.
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