Background: Cigarette smoke stimulates airway epithelial cells to release pro-inflammatory cytokines which influence various inflammation-related genes, including COX2, whereas p53 expression is known to alter in such a condition. Since both the genes share several common physiological functions including inflammation and oxidative stress, we investigated within gene and gene-gene interactions towards susceptibility to the disease.
Method: In a prospective gene-association study we conducted PCR-RFLP for genotyping the COX2 -765G/C and 8473T/C and p53 72Pro/Arg polymorphisms in 229 COPD patients and 147 healthy controls.
Results: The -765GC+CC genotypes of COX2 and Pro/Pro+Pro/Arg genotypes of p53 were prevalent in patients with significant odds ratio, 2.05 and 2.30, respectively (p=0.001; p=0.009, respectively), as a consequence, the -765C and 72Pro alleles were prevalent (p
Conclusion: The prevalence of COX2 and p53 risk-alleles contributes towards susceptibility to the disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cca.2008.07.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1.
Cell Commun Signal
January 2025
Beijing An Zhen Hospital, Capital Medical University, The Key Laboratory of Remodeling Cardiovascular Diseases, Ministry of Education; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Background: The potential role of Klebsiella pneumoniae (K.pn) in hypertension development has been emphasized, although the specific mechanisms have not been well understood. Bacterial extracellular vesicles (BEVs) released by Gram-negative bacteria modulate host cell functions by delivering bacterial components to host cells.
View Article and Find Full Text PDFNetwork pharmacological mechanism and molecular experimental validation of artemisinin in the treatment of lung adenocarcinoma.
Toxicol Appl Pharmacol
January 2025
Department of Oncology, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, China. Electronic address:
Background: Lung cancer is a medical ailment with high mortality and prevalence rates. Artemisinin (ART) and its derivatives exhibit anti-cancer properties against various malignancies, including lung cancer. However, further research is required to determine the precise anti-cancer mechanisms of ART.
View Article and Find Full Text PDFProgress in Prevention and Treatment of Dysplasia in Ulcerative Colitis Based on Cyclooxygenase-2/p53 Axis.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2024
Basic Medical College of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China.
Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by non-specific,persistent inflammation in the intestines.This chronic inflammation often increases the risk of serious complications such as colorectal cancer.Dysplasia acts as a driver of cancer development and plays a connecting role in the occurrence and development of chronic intestinal inflammation and colorectal cancer.
View Article and Find Full Text PDFPhotoprotective Effect of Taurine-Rich Protamex Extract From Salmon (Oncorhynchus keta) Byproduct Against Ultraviolet B-Induced Skin Damage in Human Dermal Fibroblasts and Zebrafish Model.
Photodermatol Photoimmunol Photomed
January 2025
Department of Medical Science and Pharmaceutical Engineering, Soonchunhyang University, Asan, Republic of Korea.
Background: Exposure to ultraviolet (UV) light promotes reactive oxygen species (ROS) production and metalloproteinase (MMP) 1 expression, leading to skin damage. Several studies have reported that protein-rich fish byproducts from enzymatic hydrolysis exhibited a variety of health benefits such as antioxidant and anti-inflammation. In the current study, we investigated the protective effect of protein hydrolysate from salmon byproduct (SBPH) in ultraviolet B (UVB)-irradiated human dermal fibroblasts (HDFs) and zebrafish.
View Article and Find Full Text PDFA Review on Hepatoprotective Effect of Chrysin: Preclinical Implications and Molecular Cascades Came into Focus.
Curr Diabetes Rev
December 2024
Department of Medical Physiology, School of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Chrysin, a flavone nutraceutical, possesses several beneficial pharmacological properties, which has gained much emphasis in recent years. The biological effects of chrysin are exerted due to impeding or activating multifarious cellular and molecular pathways. Our findings indicated that chrysin inhibited tumor progression in various cancer cell lines by repressing the formation of a sphere and upregulated protein expression of Src homology region 2 domain-containing phosphatase-1 (SHP-1), alleviating phosphorylated-signal transducer and activator of transcription 3 (p-STAT3) and transaction workflow innovation standards team1 (Twist1), sustaining phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and endorsing mitogen-activated protein kinase kinase1 (MEK1) overexpression, increasing the cytochrome c release, mitochondrial reactive oxygen species (ROS) formation, matrix metalloproteinases (MMP) collapse, and caspase-3 activity, modulating p53/ B-cell lymphoma-2 (Bcl-2)/caspase-9 cascade, cyclooxygenase- 2 (COX-2), nuclear factor kappa B proposition 65 (NF-kB p65) expression and also decreasing the expression of nuclear factor erythroid 2-related factor 2 (Nrf2).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!