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http://dx.doi.org/10.1167/iovs.08-2324 | DOI Listing |
J Microbiol Biotechnol
November 2024
Fatemah AlMalki, Biology Department, College of Science and Humanities- Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia.
is a gram-negative, facultatively anaerobic bacterium typically found in the oropharynx and respiratory tract of humans. It is responsible for various infections, including head-and-neck infections, pericarditis, and abscesses of the deltoid, perirenal tissue, brain, and liver. Increasing antibiotic resistance requires urgent identification of novel drug targets to fight this bacterium.
View Article and Find Full Text PDFChem Biodivers
January 2025
Guizhou Medical University, School of Pharmaceutical Sciences, University Town, Gui'an New District, 550025, Guiyang, CHINA.
An unrevealed dihydroflavone-monoterpene conjugate (1), two unrevealed kavalactones (2-3, including one with an uncommon side chain), and thirteen previously identified compounds (4-16) were extracted from Alpinia katsumadai Hayata. seeds. The two-dimension structures of the new compounds were authenticated utilizing HRESIMS as well as NMR spectral analysis, while their absolute chiral configurations were ascertained either by correlating the experimental and simulated values of electronic circular dichroism (ECD) patterns or conducting X-ray diffraction experiments.
View Article and Find Full Text PDFJ Asian Nat Prod Res
January 2025
Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China.
A series of C steroidal glycosides were isolated from the roots and rhizomes of (Bunge) C. Morren et Decne., including a new compound, cynatroside B (), and seven known compounds (-).
View Article and Find Full Text PDFCells
December 2024
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH, University Hospital Aachen, D-52074 Aachen, Germany.
The Rat-1 cell line was established as a subclone of the parental rat fibroblastoid line F2408, derived from Fisher 344 rat embryos. Rat-1 cells are widely used in various research fields, especially in cancer biology, to study the effects of oncogenes on cell proliferation. They are also crucial for investigating signal transduction pathways and play a key role in drug testing and pharmacological studies due to their rapid proliferation.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Inadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organo-metallic framework under ketogenic conditions in inhibiting the growth of MIA-PaCa-2 cells.
Methods: Gemcitabine was encapsulated in Metal-organic frameworks (MOFs) and its morphology and size distribution were examined using transmission electron microscopy (TEM) and Dynamic light scattering (DLS) with further characterization including FTIR analysis.
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