The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566214 | PMC |
| http://dx.doi.org/10.1128/JB.00865-08 | DOI Listing |
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