AI Article Synopsis
- Researchers designed and synthesized a new type of small molecule called a bis-indole carboxamide, which has flexible geometries alongside a constrained version.
- These new molecules are part of a novel class of compounds that can stabilize DNA structures known as G-quadruplexes.
- The G-quadruplexes are located in the promoter regions of genes crucial for cell growth, specifically c-kit2 and c-myc, suggesting potential applications in gene regulation.
Article Abstract
Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746961 | PMC |
| http://dx.doi.org/10.1039/b806042h | DOI Listing |
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