AI Article Synopsis
- Benzylic zinc reagents are created by adding zinc directly to benzylic chlorides with LiCl.
- These reagents can participate in efficient cross-coupling reactions with various aromatic halides (chlorides, bromides, and tosylates).
- The catalyst system used for these reactions consists of Ni(acac)(2) and triphenylphosphine (PPh(3)).
Article Abstract
Benzylic zinc reagents prepared by direct insertion of zinc to benzylic chlorides in the presence of LiCl undergo smooth cross-coupling reactions with aromatic chlorides, bromides and tosylates using Ni(acac)(2) and PPh(3) as a catalyst system.
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| http://dx.doi.org/10.1039/b803072c | DOI Listing |
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