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Validation of the multi-day Boston remote assessment of neurocognitive health (BRANCH) among cognitively impaired & unimpaired older adults.
J Prev Alzheimers Dis
January 2025
Department of Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA. Electronic address:
Background: The multi-day Boston Remote Assessment of Neurocognitive Health (BRANCH) is a remote, web-based assessment designed to capture the earliest cognitive changes in the preclinical stage of Alzheimer's disease (AD). It has been validated in unimpaired older adults, but as individuals progress on the AD continuum, assessments need to remain feasible and valid at different clinical stages. The focus of this study was to assess feasibility and validity of multi-day BRANCH in participants with and without cognitive impairment.
View Article and Find Full Text PDFCross-sectional and prognostic associations of baseline [F]GTP1 tau PET signal and white matter lesion volumes for cognitive and functional decline in prodromal-to-mild Alzheimer's disease.
J Alzheimers Dis
January 2025
Genentech, Inc., South San Francisco, CA, USA.
Background: In Alzheimer's disease (AD), tau and white matter lesion pathology are associated with clinical severity and subsequent decline, but their relative relationships with clinical assessments remain uncertain.
Objective: To examine cross-sectional and prognostic associations between baseline [F]GTP1 tau positron emission tomography (PET) standardized uptake value ratio (SUVRs) and T1 white matter hypointensity (WMHypo) volumes with clinical indices.
Methods: We analyzed participants with biomarker-confirmed prodromal (n = 127) or mild (n = 233) AD with baseline [F]GTP1 tau PET and MRI and longitudinal Clinical Dementia Rating-Sum of Boxes (CDR-SB), 13-item version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog13), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Mini-Mental Status Examination (MMSE), and Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) data.
EGb761 Trials for Mild-to-Moderate Dementia-What Have We Learned in the Past 18 years?
Am J Ther
January 2025
Faculty of Medicine, "Transilvania" University, Brasov, Romania; and.
Background: Dementia leads to cognitive decline affecting memory, thinking, and behavior. Current pharmaceutical treatments are symptomatic, with limited efficacy and significant drawbacks. Ginkgo biloba extract (EGb761) is being explored as an adjuvant therapy for dementia because of its potential neuroprotective effects.
View Article and Find Full Text PDFCorrelation Study Between TV Viewing Variables and Cognitive Level, Depression Level, and Activities of Daily Living in Older Individuals Living Alone.
Healthcare (Basel)
December 2024
Department of Physical Therapy, Sun Moon University, Asan 31460, Republic of Korea.
Although there are studies on TV viewing and the health status of elderly, they do not present direct associations with specific variables. The aim of this study was to determine correlations between TV viewing variables and elderly health variables in older adults living alone. Data were collected from 50 elderly individuals with an average age of 82.
View Article and Find Full Text PDFEvaluation of Depression and Cognitive Status in Geriatric Patients Undergoing Orthopedic Surgery.
Acta Chir Orthop Traumatol Cech
January 2025
Department of Orthopaedics and Traumatology, Faculty of Medicine, Kütahya Health Sciences University, Kütahya, Turkey.
Purpose Of The Study: Cognitive disorders are common in geriatric surgical patients We conducted a study to evaluate depression and cognitive behavior in geriatric patients undergoing orthopedic surgery.
Material And Methods: This descriptive cross-sectional study was conducted at a university hospital in Turkey, involving 262 elderly patients who underwent orthopedic surgeries. Data were collected using The Patient Information Form, Standardized Mini-Mental Test, and Geriatric Depression Scale.
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