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From setbacks to success: lessons from the journey of RSV vaccine development.
Ther Adv Vaccines Immunother
December 2024
Centre for Human Drug Research, Leiden, The Netherlands.
Respiratory syncytial virus (RSV) causes high worldwide infant mortality, as well as a high disease burden in the elderly. Efforts in vaccine development over the past 60 years have recently delivered three approved vaccines and two monoclonal antibodies (mAbs). Looking back at the eventful history of RSV vaccine development, several factors can be identified that have hampered the developmental pathway, including the occurrence of enhanced RSV disease (ERD) in the first vaccine attempt and the difficulty in characterizing and stabilizing the pre-fusion F protein as a vaccine target.
View Article and Find Full Text PDFAddiction treatment and harm reduction programs in prisons: lessons from Iran.
Int J Prison Health (2024)
December 2024
Department of addiction, School of behavioural sciences and mental health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran.
Purpose: Substance use disorder is one of the most prevalent health issues among prison populations. In this regard, addiction treatment and harm reduction programs have been implemented in Iranian prisons since 2002. The purpose was to describe the practical experience of implementing harm reduction programs in Iran's prisons, emphasizing the impact of policy decisions on it.
View Article and Find Full Text PDFA rare perspective: fine-needle aspiration cytologic features of hyaline vascular type of Castleman disease: A case report.
Medicine (Baltimore)
December 2024
Departments of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei, China.
Rationale: Castleman disease, also known as Castleman syndrome, is a rare, nonmalignant lymphoproliferative disorder. The localized subtype of this disease is primarily the hyaline vascular type of Castleman disease (HVCD). Although this disease is a benign lesion, the histologic features are similar to those of some malignant lymphomas, so an accurate diagnosis of the disease is required.
View Article and Find Full Text PDFMobilizing community engagement for crisis response: lessons learned from a COVID-19 mass vaccination clinic in Cobourg, Ontario, Canada.
BMC Public Health
December 2024
Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Background: Communities have an important role to play in disaster and emergency planning and response. Yet community members are not typically engaged in official planning activities, including plans for mass immunization clinics during infectious disease emergencies, such as the COVID-19 pandemic. This qualitative study explores one case of a community driven effort to implement a COVID-19 mass vaccination clinic in Cobourg, Ontario, Canada.
View Article and Find Full Text PDFLiver cirrhosis complicated with pulmonary Nocardia infection: A case report and literature review.
Medicine (Baltimore)
December 2024
Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Rationale: Nocardia is a conditionally pathogenic bacterium found in the natural environment and is an aerobic bacterium, which causes severe pneumonia relatively rarely. The diagnosis of primary Nocardia infection is always made late due to the nonspecific clinical presentation of patients with Nocardia infection and the time required for Nocardia culture. Due to its rarity and nonspecific clinical presentation, patient survival is often compromised due to misdiagnosis.
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