AI Article Synopsis
- Investigations of the marine-derived fungus Chaetomium sp. led to the discovery of new natural products called chaetoxanthones A, B, and C, with unique structural features.
- Compounds 1 and 2 contain a rare dioxane/tetrahydropyran moiety, while compound 3 is a chlorinated xanthone with a tetrahydropyran ring.
- Compound 2 demonstrated strong selective activity against the malaria-causing parasite Plasmodium falciparum, while compound 3 showed moderate activity against Trypanosoma cruzi, the causative agent of Chagas disease.
Article Abstract
Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new natural products chaetoxanthones A, B, and C (1-3). Compounds 1 and 2 are substituted with a dioxane/tetrahydropyran moiety rarely found in natural products. Compound 3 was identified as a chlorinated xanthone substituted with a tetrahydropyran ring. The configurational analysis of these compounds employed CD spectroscopy, modified Mosher's method, and selective NOE gradient measurements. Compound 2 showed selective activity against Plasmodium falciparum with an IC50 value of 0.5 microg/mL without being cytotoxic toward cultured eukaryotic cells. Compound 3 displayed a moderate activity against Trypanosoma cruzi with an IC50 value of 1.5 microg/mL.
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| http://dx.doi.org/10.1021/np800294q | DOI Listing |
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