AI Article Synopsis
- The objective of the study is to describe the clinical and pathological aspects of primary NK/T cell lymphoma in the lung, focusing on two reported cases along with a literature review.
- Most patients exhibited symptoms like fever, cough, and difficulty breathing, with imaging showing nodules and pleural effusions, all often without typical lymph node swelling; Ebstein-Barr virus was found in some cases.
- The study concluded that although rare, this type of lymphoma should be considered in patients with lung-related symptoms that don't improve with antibiotics, especially if accompanied by low white blood cell counts and high LDH levels.
Article Abstract
Objective: To describe the clinical and pathological features of primary NK/T cell lymphoma of the lung.
Methods: Two cases of primary NK/T cell lymphoma of the lung were reported, and the clinical, radiological and pathological characteristics of the disease were discussed with literature review of 3 cases.
Results: Most patients presented with fever, cough and dyspnea, and antibiotics were ineffective. Radiographic findings included solitary or multiple nodules and consolidation, unilateral orbilateral pleural effusions (4/5), without hilar or mediastinal adenopathy. Ebstein-Barr virus was positive in cases patients (3/5). Histopathology revealed a great deal of abnormal lymphocyte infiltration, which were angio-centric with marked tissue putrescence and angio-destruction. Immunophenotyping showed CD56(+), CD3(+), perform (+), T-cell intracytoplasmic antigen-1(+) and/or GranB(+), but CD20(-). Most patients died of respiratory failure in half a year (4/5).
Conclusion: Primary NK/T cell lymphoma of the lung is rare, but should be considered when patients present with lung shadows and fever non-responsive to antibiotics, decreased WBC and increased LDH.
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