Goals Of Work: Determining resuscitation status (RS) for inpatients with advanced cancer is emotionally charged and often conflictual. Available data suggest that clinicians have inconsistent practices when establishing and documenting do-not-resuscitate (DNR) orders. Lack of standardization may contribute to ineffective and unclear discussions regarding RS. To inform revisions of DNR order forms used at one comprehensive cancer center, we surveyed National Cancer Institute-designated cancer centers (NCICCs) to determine if a standardized approach to documenting inpatient DNR orders exists.
Materials And Methods: Over a 12-week period in 2002-2003, the 50 NCICCs providing inpatient care were contacted regarding participation in this Institutional Review Board-approved study. Using a 69-item database, inpatient DNR order forms were analyzed for content and elements of process used to establish and document RS. Each form was evaluated by two raters to assess inter-rater reliability. Analysis was descriptive; inter-rater agreement was summarized using the kappa statistic.
Main Results: Sixty percent (30 out of 50) of NCICCs participated. Eighty percent of responding sites confined the order process exclusively to cardiopulmonary resuscitation and did not include other interventions for possible limitation. Two thirds of responding sites used preformatted order forms specific for establishing inpatient RS; forms varied widely in content and elements of process used to establish and document DNR orders.
Conclusions: NCICCs do not have a standardized approach to establishing and documenting DNR orders. Lack of standardization may reflect the absence of a common understanding of these difficult issues which may contribute to unclear and ineffective communication when addressing RS.
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http://dx.doi.org/10.1007/s00520-008-0490-5 | DOI Listing |
Sci Adv
January 2025
Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore 308232, Singapore.
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January 2025
College of Chemistry, Key Laboratory of Theoretical and Computational Photochemistry, Beijing Normal University, Beijing 100875, China.
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Fondazione FIRMO Onlus, Italian Foundation for the Research On Bone Diseases, Florence, Italy.
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January 2025
Department of Mathematics and Mathematical Statistics, Umeå University, Umeå 90187, Sweden.
Multicellularity spans a wide gamut in terms of complexity, from simple clonal clusters of cells to large-scale organisms composed of differentiated cells and tissues. While recent experiments have demonstrated that simple forms of multicellularity can readily evolve in response to different selective pressures, it is unknown if continued exposure to those same selective pressures will result in the evolution of increased multicellular complexity. We use mathematical models to consider the adaptive trajectories of unicellular organisms exposed to periodic bouts of abiotic stress, such as drought or antibiotics.
View Article and Find Full Text PDFProtein Sci
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Department of Cell Biology and Genetics, Texas A&M Health Science Center, Texas A&M University, Bryan, Texas, USA.
The Drosophila intrinsically disordered protein Ultrabithorax (Ubx) undergoes a series of phase transitions, beginning with noncovalent interactions between apparently randomly organized monomers, and evolving over time to form increasingly ordered coacervates. This assembly process ends when specific dityrosine covalent bonds lock the monomers in place, forming macroscale materials. Inspired by this hierarchical, multistep assembly process, we analyzed the impact of protein concentration, assembly time, and subphase composition on the early, noncovalent stages of Ubx assembly, which are extremely sensitive to their environment.
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