Bispyrrolidinoindoline diketopiperazine alkaloids were synthesized from a common intermediate in seven steps from commercially available amino acids. This versatile synthetic strategy has led to the accomplishment of the first total synthesis of heterodimeric WIN 64745 and a novel approach to homodimeric WIN 64821.
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| http://dx.doi.org/10.1021/ol8013073 | DOI Listing |
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