Multicentric reticulohistiocytosis (MRH) is a rare multisystem disease characterized by skin nodules and a destructive polyarthritis. We describe cardiac disease in a 42-year-old African American female with a history of MRH for 29 years and dilated cardiomyopathy for 5 years. During a congestive heart failure flare, the patient was slow to respond to standard treatment. A left/right heart catheterization and endomyocardial biopsy were performed, and the patient was found to have evidence of myocardial MRH infiltration.
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Multicentric Reticulohistiocytosis.
Skinmed
January 2025
Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA;
A Caucasian woman in her twenties having asymptomatic papules on the hands for the past 6 months was referred by rheumatology for a skin biopsy. The patient had presented to rheumatologist for arthralgia. On physical examination, multiple, dull red, 2-5-mm papules were observed on her dorsal fingers, with most in the periungual regions.
View Article and Find Full Text PDFPediatric Solitary Epithelioid Histiocytoma of the Face.
J Craniofac Surg
November 2024
Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin.
Background: Solitary epithelioid histiocytoma, also known as reticulohistiocytoma, is a rare benign histiocytic proliferation with an unreported incidence that commonly presents as a superficial nodule involving the trunk and extremities of adults. Pathology shows dermal histiocytic infiltration composed of large, eosinophilic histiocytes with "glassy" cytoplasm and oncocytic macrophages. When presenting as part of a systemic disorder, it is called multicentric reticulohistiocytosis, a rare and more aggressive condition characterized by multiple skin and mucosal lesions and arthritis.
View Article and Find Full Text PDFMulticentric reticulohistiocytosis: A 20-year diagnosis beneath the surface.
Reumatol Clin (Engl Ed)
October 2024
Servicio de Reumatología, Complexo Hospitalario de Vigo, Pontevedra, Spain; Grupo IRIDIS (Investigation in Rheumatology and Immune-mediated Diseases), Instituto de Investigación Sanitaria Galicia Sur, Vigo, Pontevedra, Spain.
Generalized Eruptive Histiocytosis or Juvenile Xanthogranuloma: A Clinicopathological Conundrum of Coexistence or Xanthomatization.
Indian Dermatol Online J
July 2024
Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, India.
Article Synopsis
- Diseases classified under non-LCH often have similar clinical and histological characteristics, making diagnosis difficult.
- A two-year-old girl exhibited various asymptomatic skin lesions, leading to a provisional diagnosis of generalized eruptive histiocytosis (GEH), which was later found to have overlapping features with juvenile xanthogranuloma (JXG).
- The case highlights the importance of careful differentiation between GEH and JXG since they may require different treatment approaches, demonstrating that clinical observation alone can be misleading due to their similarities.
Multicentric reticulohistiocytosis with good response to tocilizumab.
Med Clin (Barc)
December 2024
Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital General Universitario Reina Sofía, Murcia, España.
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