Context: Accumulating evidence suggests that estrogens may have therapeutic effects in severe mental illnesses, including schizophrenia, via neuromodulatory and neuroprotective activity.
Objective: To compare the efficacy of adjunctive transdermal estradiol with that of adjunctive placebo in the treatment of acute psychotic symptoms.
Design: Randomized, double-blind study.
Setting: Patients were recruited from inpatient acute hospital wards and outpatient clinics of 2 metropolitan Melbourne general hospitals.
Participants: One hundred two women of childbearing age with schizophrenia. All participants were in an acute or chronic phase of their illness; 73 participants were outpatients and the rest were inpatients. Intervention Patients were randomized to receive 100 microg of transdermal estradiol (n = 56) or transdermal placebo (n = 46) for 28 days.
Main Outcome Measures: Psychopathological symptoms were assessed weekly with the Positive and Negative Syndrome Scale.
Results: The addition of 100 microg of transdermal estradiol significantly reduced positive (P < .05) and general psychopathological (P < .05) symptoms during the 28-day trial period compared with women receiving antipsychotic medication alone.
Conclusion: Estradiol appears to be a useful treatment for women with schizophrenia and may provide a new adjunctive therapeutic option for severe mental illness.
Trial Registration: clinicaltrials.gov Identifier: NCT00206570.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archpsyc.65.8.955 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Post-Traumatic Epilepsy on Mental Health and Multidimensional Outcome and Quality of Life: An NIDILRR TBIMS Study.
J Neurotrauma
January 2025
Department of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Traumatic brain injury (TBI) and subsequent post-traumatic epilepsy (PTE) often impair daily activities and mental health (MH), which contribute to long-term TBI-related disability. PTE also affects driving capacity, which impacts functional independence, community participation, and satisfaction with life (SWL). However, studies evaluating the collective impact of PTE on multidimensional outcomes are lacking.
View Article and Find Full Text PDFThe purpose of this research is to describe the factors affecting hazardous chemotherapy exposure and strategies to foster chemotherapy safety among oncology nurses. Fifteen oncology nurses and 5 oncology nurse managers were recruited from 2 medical centers in the Midwest United States through convenience purposive sampling. A qualitative descriptive approach was employed.
View Article and Find Full Text PDFRisk factors and resolution of patient-reported pain and mental health symptoms following rib fracture(s).
J Trauma Acute Care Surg
January 2025
From the Department of Surgery, University of Minnesota Medical School (M.S., K.S.); Department of Surgery (E.K.J., D.M., J.M.-D.), University of Minnesota; Fairview Health Services, Trauma Services, (M.B., M.D.); and Department of Surgery (G.B.M.-M., C.J.T.), Institute for Health Informatics (G.B.M.-M., C.T.), and Center for Learning Health System Sciences (G.B.M.-M., C.T.), University of Minnesota, Minneapolis, Minnesota.
Background: Rib fractures, constituting 10% to 15% of trauma admissions, contribute significantly to morbidity and mortality. Effective postdischarge patient care remains a challenge. Our system has operationalized patient-reported outcome measures (PROMs) via a mobile platform into routine postdischarge monitoring for rib fracture patients.
View Article and Find Full Text PDFComparing peer relationship ratings among adolescents with sport and Non-sport Related Concussions.
Phys Sportsmed
January 2025
Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, USA.
Objective: To evaluate if peer relationship ratings differ among adolescents who sustain a sport-related concussion compared to those who sustain a non-sport-related concussion.
Study Design: We conducted a cross-sectional investigation of 123 adolescents who sustained a concussion within 21 days before their initial post-injury evaluation (mean = 9.2 ± 3.
Systematic Review and Meta-Analysis: Risk Factors of Violence During First-Episode Psychosis.
Trauma Violence Abuse
January 2025
Orygen, Parkville, Melbourne, VIC, Australia.
Most people with a psychotic illness will never be violent; however, it is widely known that violence is more prevalent in this group compared to the general community, particularly during first-episode psychosis (FEP). Despite this, there is limited research into what contributes to this increased risk during FEP. The present systematic review aimed to identify whether certain risk factors are differentially associated with severity and timing of violence perpetration during FEP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!