Lymphoepithelial cysts of the pancreas: endosonography-guided fine needle aspiration.

Diagn Cytopathol

Department of Pathology and Laboratory Medicine, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania 19104, USA.

Published: September 2008

AI Article Synopsis

  • Lymphoepithelial cysts (LECs) in the pancreas are rare benign lesions, with three male cases reported from 2007, ages 47 to 77.
  • Each patient had a single incidental cystic mass in the pancreatic body/tail, measuring 3 to 6.5 cm, which was characterized by endosonography (EUS) as a well-defined lobulated mass.
  • Fine needle aspiration (FNA) analysis revealed specific cellular components, aiding diagnosis and potentially avoiding unnecessary surgical procedures, with one case confirmed via surgery.

Article Abstract

Lymphoepithelial cyst (LEC) of the pancreas is a rare lesion. Here, we report three cases that we encountered during 2007 in our institution, which were evaluated by endosonography (EUS) and fine needle aspiration (FNA). All three patients were male with ages ranging from 47 to 77 years. Each patient had a single, cystic mass of the body/tail of the pancreas that was found incidentally on CT scan. The size of the masses ranged from 3 to 6.5 cm radiologically. For each patient, EUS showed a well-circumscribed, lobulated mass with smooth contours; the remainder of the pancreas appeared normal without ductal dilation. FNA of all three masses demonstrated predominantly anucleated squamous cells, amorphous keratinous debris, and lymphocytes. Cholesterol crystals were present in one case. One patient underwent surgical resection and the diagnosis of LEC was confirmed histologically. In conclusion, pancreatic LECs are extremely rare, benign cystic lesions. FNA study may help to render a correct diagnosis and reduce unnecessary surgery.

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http://dx.doi.org/10.1002/dc.20865DOI Listing

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