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Antileishmanial activity of aldonamides and N-acyl-diamine derivatives. | LitMetric
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Antileishmanial activity of aldonamides and N-acyl-diamine derivatives.

Elaine S Coimbra Camila G Almeida Wilson V Júnior Roberta C N Dos Reis Ana C F De Almeida Luana S M Forezi Mauro V De Almeida Mireille Le Hyaric

ScientificWorldJournal

Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de CiênciasBiológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, Brazil.

Published: July 2008

A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 microM.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848739PMC
http://dx.doi.org/10.1100/tsw.2008.100DOI Listing

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