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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages.
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Laboratório de Imunologia Clínica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, 21040-360, Brazil.
Background: Leishmaniases are neglected tropical diseases with great clinical and epidemiological importance. The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. The discovery of new therapeutic alternatives is extremely essential, and the discovery of cellular targets is a tool that helps in the development of new drugs.
View Article and Find Full Text PDFMolecular evidence for the role of the ovipositor of the fall armyworm: Where to lay or not to lay?
Insect Sci
January 2025
Institute of Plant Protection, Guangdong Academy of Agricultural Sciences, Key Laboratory of Green Prevention and Control on Fruits and Vegetables in South China Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of High Technology for Plant Protection, Guangzhou, China.
Oviposition behavior in insects has received considerable attention, but studies have mainly focused on the antennae, neglecting the role of the ovipositor. In this study, we investigated the functional characteristics of the ovipositor in oviposition site selection by the fall armyworm (FAW) Spodoptera frugiperda, a destructive invasive pest of maize and other cereals. In oviposition choice assays females exhibited significant repellency to isothiocyanate (ITC), volatiles specific to non-preferred cruciferous plants.
View Article and Find Full Text PDFStrategies to promote the provision of sexual health services during menopause: a qualitative study from the perspective of menopausal women and healthcare providers in Isfahan city, Iran.
BMC Health Serv Res
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Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: It is important to care for the sexual function of women during menopause as it can affect their quality of life. However, the services related to this area have been neglected in the health system and are not provided at the desired level. Therefore, the present study aimed to identify strategies to promote the provision of sexual health services during menopause in Isfahan city, Iran.
View Article and Find Full Text PDFAdvantages and disadvantages of current human enteric virus surrogates in soils and aquifers.
Sci Total Environ
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College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083, China.
Groundwater is one of the main sources of drinking water, thus, human enteric viruses in groundwater could pose safety risks. Many enteric viruses enter drinking water sources through irrigation or recharge of contaminated water. It is therefore advised to test the potential transport risk with harmless surrogates before wastewater or recycled water is used for irrigation or groundwater recharge.
View Article and Find Full Text PDFPrevalence of asymptomatic Leishmania donovani infection and associated factors in Ethiopia: a systematic review and meta-analysis.
BMC Infect Dis
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Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Background: Visceral leishmaniasis is endemic in Ethiopia and caused by Leishmania donovani. Although the disease manifests with significant clinical variability, a substantial number of individuals are asymptomatic. These individuals can serve as reservoirs, complicating control efforts.
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