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Dapsone-induced methemoglobinemia in a child with leprosy.
An Bras Dermatol
January 2025
Dermatology Clinic, Hospital da Santa Casa de São Paulo, São Paulo, SP, Brazil; Discipline of Dermatology, Faculty of Medical Sciences, Santa Casa de São Paulo, São Paulo, SP, Brazil.
Regional readiness for sodium nitrite-induced methemoglobinemia: availability of methemoglobin testing and methylthioninium chloride (methylene blue) stocking in the Upper Midwestern United States.
Clin Toxicol (Phila)
January 2025
Minnesota Regional Poison Center, Minneapolis, MN, USA.
Introduction: Sodium nitrite is a potent oxidizer, which may precipitate rapidly lethal methemoglobinemia. Prompt diagnosis and treatment may salvage otherwise fatal cases. It is unclear if emergency departments are prepared for increasing cases.
View Article and Find Full Text PDFAcute hemolytic crisis complicated with ischemic cardiac injury and methemoglobinaemia following ingestion of naphthalene: a case report.
J Med Case Rep
December 2024
Faculty of Healthcare Sciences, Eastern University of Sri Lanka, Chenkaladi, Sri Lanka.
Background: Naphthalene is an aromatic hydrocarbon that potentially produces methemoglobinaemia but rarely causes hemolysis, especially in children with underlying glucose-6-phosphate dehydrogenase deficiency. Although ingestion of a single moth ball by an older child may not be life threatening, it can be fatal if ingested by a toddler.
Case Presentation: A 2-year-old Singhalese boy developed acute severe hemolysis and methemoglobinaemia following ingestion of a mothball.
Methaemoglobinaemia in neonates with acute gastroenteritis: lethal, but curable.
BMJ Case Rep
December 2024
Neonatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamilnadu, India.
Article Synopsis
- Methaemoglobinaemia is a rare condition that can cause cyanosis, often linked to anaesthetic agents, but this case series highlights three instances related to acute gastroenteritis from formula feeds in newborns.
- The infants presented with symptoms of hypoxia, metabolic acidosis, and diarrhea, which can complicate the usual diagnosis, emphasizing the need for awareness of this condition.
- Rapid identification and treatment with methylene blue and fluid therapy were crucial, leading to successful recovery and discharge on exclusive breast feeds.
Risky Remedy: Rasburicase-Induced Methemoglobinemia in Tumor Lysis Syndrome Complicated by G6PD Deficiency.
Cureus
November 2024
Hematology and Medical Oncology, University of Kentucky College of Medicine, Lexington, USA.
Tumor lysis syndrome (TLS) is a critical oncologic emergency characterized by metabolic disturbances resulting from rapid cancer cell lysis. Rasburicase, a recombinant urate oxidase, is the primary treatment for hyperuricemia in TLS but poses a risk for methemoglobinemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. We present the case of a 59-year-old male with diffuse large B-cell lymphoma (DLBCL) who developed spontaneous TLS.
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