Five examples of a distinctive sebaceous malformation, designated "folliculosebaceous cystic hamartoma," form the basis of this study. Criteria are proposed for specific diagnosis of this hamartoma and for differentiation of it from sebaceous gland hyperplasia, steatocystoma, dermoid cyst of skin, and sebaceous trichofolliculoma.

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The skin covers our body and exhibits a complex structure that is adapted to the different body areas. The scalp skin is distinctive, and the histopathological alterations in its diseases also present distinctive features. We present the clinical case of a 28-year-old female patient, with no significant medical history.

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Article Synopsis
  • Folliculosebaceous cystic hamartoma (FSCH) is a rare skin growth that contains both epithelial and mesenchymal tissue, usually presenting as a slow-growing, skin-colored nodule on the face or scalp.
  • A case is highlighted involving a 45-year-old male with a 4 mm nodule on his temple, which was initially misidentified as an epidermal inclusion cyst (EIC), but further examination confirmed it was FSCH due to its unique structure.
  • The standard treatment for FSCH is surgical excision, and post-surgery, the patient has not experienced any recurrence, emphasizing the need to distinguish FSCH from EIC in similar cases.
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Article Synopsis
  • - A 12-year-old girl had a rare benign skin cyst on her scalp, which was found to contain features of both pilar (hair follicle) and apocrine (sweat gland) differentiation.
  • - The cyst was successfully removed through a collaboration between a plastic surgeon and a neurosurgeon.
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Giant Folliculosebaceous Cystic Hamartoma of the Face.

Dermatopathology (Basel)

December 2023

Department of Dermatology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany.

Folliculosebaceous cystic hamartoma (FSCH) is a rare and benign form of cutaneous hamartomas. These skin lesions often lead to clinical and histopathological misdiagnosis due to their similarities to cutaneous lesions with overproduction of clustered sebaceous glands. Clinically, the lesions often present as solitary, skin-colored, pedunculated warts to cauliflower-like, exophytic papules and nodules, usually with a diameter ranging 0.

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