AI Article Synopsis
- Infections are a significant concern for pediatric renal transplant (RT) recipients, with over half experiencing at least one infection during the first two years post-transplant.
- The study found that the most common type of infection was urinary tract infections (UTIs), with a notable prevalence of antibiotic-resistant bacteria (ESBL producers).
- A key risk factor identified for these infections was a longer cold ischemia time of over 800 minutes, suggesting that minimizing this time may help reduce infection rates.
Article Abstract
Unlabelled: Infections are frequent and serious in pediatric RT recipients; however, the information available is scarce. The aim of this study was to determine the incidence, etiology, and risk factors for infection in these patients. This was a prospective, observational study of a consecutive pediatric RT recipient cohort. Risk factors for infection and descriptive analyses during the first two post-transplantation years were performed. Twenty-one patients (58.3%) had at least one infection (incidence 1.5 episodes/patient/first year of transplantation). There were 33 bacterial infections (73.3%), 11 viral infections (24.4%), and one protozoal infection. UTI was the most common syndrome (48.3%), followed by CMV infection (15.5%). The main microorganisms isolated were Escherichia coli (28.9%), 46.1% of which were ESBL producers, and CMV (20%). Patient and graft survival at the end of follow-up were 97.2% and 83.3%, respectively. The only risk factor for infection was cold ischemia time >800 min (OR 5.7, CI 95% 1.7-19.3).
Conclusions: In pediatric RT recipients, UTI is the most frequent syndrome. Bacterial infections are the most common, with a high rate of ESBL producer strains. Despite their good prognosis, infections are a cause of morbidity that could potentially be reduced by decreasing cold ischemia times.
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| http://dx.doi.org/10.1111/j.1399-3046.2008.01019.x | DOI Listing |
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