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Drug Property Optimization: Design, Synthesis, and Characterization of Novel Pharmaceutical Salts and Cocrystal-Salt of Lumefantrine.
Mol Pharm
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of spp. and prevents malaria pathogens from producing nucleic acid and protein, thereby eliminating the parasites.
View Article and Find Full Text PDFPrevalence and type of removable prostheses manufactured in dental laboratories in Switzerland over the last 10 years.
Swiss Dent J
January 2025
Division of Gerodontology and Removable Prosthodontics, University Clinics of Dental Medicine, University of Geneva, Geneva, Switzerland.
Due to effective preventive measures and advanced techniques in operative dentistry, tooth loss occurs later in life and implant restorations have become a common solution for replacement of missing teeth. Therefore, the use of removable dental prostheses (RDPs) is expected to decline over time. This study aims to evaluate the expected decrease in the production of RDPs in Swiss dental laboratories over the past decade.
View Article and Find Full Text PDFOptimizing pre-eclampsia prevention: Embracing low-dose calcium in sub-Saharan Africa.
Int J Gynaecol Obstet
January 2025
Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Pre-eclampsia remains a significant health challenge in sub-Saharan Africa, contributing substantially to maternal and neonatal mortality rates. This paper explores the potential of low-dose calcium supplementation as an alternative strategy to the conventional high-dose regimen in preventing pre-eclampsia. A consistent association between low serum calcium levels and an increased risk of pre-eclampsia is established based on studies spanning Ghana, Nigeria, and Ethiopia.
View Article and Find Full Text PDF2024 HRS perspective on advancing workflows for CIED remote monitoring.
Heart Rhythm O2
December 2024
Philips, San Diego, California.
Cardiac implantable electronic devices (CIEDs) generate substantial data, often stored in image or PDF formats. Remote monitoring, now an integral component of patient care, places considerable administrative burdens on clinicians and staff, in large part due to the challenge of integrating these data seamlessly into electronic health records. Since 2006, the Heart Rhythm Society, in collaboration with the CIED industry, has led an initiative to establish a unified standard nomenclature.
View Article and Find Full Text PDFExperimental Evaluation of Ocular Rigidity and Pressure-Volume Relationship After Ex-Vivo Scleral Cross-Linking With Riboflavin and Ultraviolet A in Porcine Eyes.
Cureus
December 2024
Ophthalmology, Medical School, Institute of Vision and Optics, University of Crete, Heraklion, GRC.
Purpose: Scleral cross-linking (SXL) with ultraviolet A (UVA) and riboflavin has already been used in laboratory studies for scleral stiffness increase as a potential treatment for progressive myopia and scleral ectasia. This study aims to investigate whether the regional application of scleral cross-linking (SXL) with ultraviolet A (UVA) and riboflavin in fresh porcine eye globes affects the ocular rigidity as well as its impact on intraocular pressure after an induced acute increase in the volume of intraocular fluid.
Methods: The study included two groups of fresh porcine eyes: an experimental group (n=20) that underwent scleral cross-linking (SXL) with riboflavin and UVA applied to the posterior sclera and a control group (n=20) that did not receive SXL treatment.
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