AI Article Synopsis

  • The study investigates the demographic factors influencing central corneal thickness (CCT) among Northwestern American Indians/Alaskan Natives (AI/ANs) and compares these measurements to those of White and African-American populations.
  • CCT was measured using ultrasonic pachymetry on a random sample of 429 AI/AN participants, revealing that their average CCT (554.8 microm) is thicker than that of African Americans but similar to that of Whites.
  • The findings indicate that AI/AN females have thicker CCT than males, yet there are no significant differences based on age, heritage, or glaucoma status, highlighting the need for further research on glaucoma risk factors among AI/ANs.

Article Abstract

Purpose: To determine the demographic factors associated with central corneal thickness (CCT) in Northwestern American Indians/Alaskan Natives (AI/ANs) and to compare these CCT measurements with those of White and African-American persons.

Design: Cross-sectional comparative, observational study.

Methods: We performed ultrasonic pachymetry (DGH-500 Pachette; DGH Technologies, Exton, Pennsylvania, USA) on a random sample of AI/AN subjects from three randomly selected AI/AN tribes in the Northwest United States (n = 429). Pachymetry also was performed on a convenience sample of White (n = 46) and African-American (n = 33) persons. Our main outcome measure was the average of right and left eye CCT.

Results: Average AI/AN CCT was 554.8 +/- 33.9 microm. AI/AN CCT was found to be thicker than that of African Americans (528.5 +/- 33.2 microm) but similar to that of White persons (551.9 +/- 28.3 microm). CCT was greater in AI/AN females than in AI/AN males (557.6 +/- 33.3 microm vs 550.1 +/- 34.5 microm; P = .03). We found no difference in CCT based on percent AI/AN heritage, age, and keratometry readings. We found no significant differences in mean CCT between AI/ANs with glaucoma (556.2 microm) and those who did not have glaucoma (556.6 microm).

Conclusions: CCT measurements for the Northwest AI/AN population are similar to those of White persons but thicker than those of African-American persons. Although glaucoma is common in AI/ANs, we did not find an association with thin CCT. We need future studies to explore the risk factors for glaucoma in AI/ANs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586824PMC
http://dx.doi.org/10.1016/j.ajo.2008.05.047DOI Listing

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