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A pilot human study using ketamine to treat disorders of consciousness.
iScience
January 2025
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Post-comatose disorders of consciousness (DoC) represent persistent neurological conditions with limited therapeutic options and a poor prognosis. Recent works advocate for exploring the effects of psychedelics to enhance brain complexity in DoC and ameliorate their consciousness. We investigated sub-anesthetic concentration of the atypical psychedelic ketamine for treating post-comatose prolonged DoC through a double-blind, placebo-controlled, cross-over trial involving three adult patients.
View Article and Find Full Text PDFCardiac Myxoma Associated With Supraventricular Tachycardia as an Unusual Cause of Unilateral Pulmonary Edema.
JACC Case Rep
January 2025
General Surgery Department, Hospital General Dr Manuel Gea González, Mexico City, Mexico.
A 34-year-old man with sudden palpitations, dyspnea, and chest pain was found to have tachycardia and unilateral pulmonary congestion. Intravenous adenosine restored sinus rhythm. Imaging and pathology confirmed an atrial myxoma with severe mitral regurgitation, requiring surgical excision and mitral valve replacement.
View Article and Find Full Text PDFKaposi's sarcoma unmasked by corticosteroids in an advanced HIV patient with tuberculosis immune reconstitution inflammatory syndrome.
Indian J Sex Transm Dis AIDS
December 2024
Department of Pathology, AIG Hospitals, Gachibowli, Hyderabad, Telangana, India.
In this case report, we present a 35-year-old homosexual man with advanced HIV disease and disseminated tuberculosis (TB) who developed paradoxical TB immune reconstitution inflammatory syndrome (IRIS). Corticosteroids, vital in life-threatening IRIS, were initiated, resulting in symptom resolution but unmasking AIDS-associated Kaposi's sarcoma (KS). Diagnostic confirmation revealed disseminated KS, necessitating a comprehensive therapeutic strategy involving chemotherapy and thalidomide as a steroid-sparing agent.
View Article and Find Full Text PDFMonitoring neoadjuvant treatment-induced surgical benefit in GIST patients using CT-based radiological criteria.
Surg Open Sci
August 2024
Department of Surgical Oncology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Objective: This single-centre retrospective study aims to determine the incidence of therapy-induced surgical benefit in patients with non-metastatic gastrointestinal stromal tumour (GIST) treated with neoadjuvant tyrosine kinase inhibitors (TKI) and evaluate whether this can be predicted by radiological response criteria.
Methods: Thirty-nine non-metastatic GIST patients were treated with neoadjuvant TKI treatment, followed by curative-intended surgery, and monitored using contrast-enhanced computed tomography (CE-CT). Surgical benefit was independently assessed by two surgical oncologists and was defined by de-escalation of surgical strategy or reduced surgical complexity.
The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function.
Front Immunol
January 2025
Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Introduction: Chimeric antigen receptor (CAR) expressing T-cells have shown great promise for the future of cancer immunotherapy with the recent clinical successes achieved in treating different hematologic cancers. Despite these early successes, several challenges remain in the field that require to be solved for the therapy to be more efficacious. One such challenge is the lack of long-term persistence of CD28 based CAR T-cells in patients.
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