Correlation was revealed between the ultrastructure of hepatocyte contacts and force F, essential for the rupture of the junction between the cell, seized with a microneedle, and the tissue specimen, in mice of the highly cancerous CBA line and of the low cancerous C57BL line at the age of 1.7 and 15 months. The most considerable ultrastructural differences in the cell contacts were found in the above mice at the age of 1 month, when the signs of carcinogenic process cannot yet been seen. It is shown that the differences in force F of these mice are not associated with the structural changes in hepatocyte contacts which may be due to the differences in durability properties of the cytoskeleton.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis.
J Transl Med
January 2025
The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; The Qingyuan Affiliated Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China.
Chronic liver diseases are highly linked with mitochondrial dysfunction and macrophage infiltration. Mallory-Denk bodies (MDBs) are protein aggregates associated with hepatic inflammation, and MDBs pathogenesis could be induced in mice by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). Here, we investigate the macrophage heterogeneity and the role of macrophage during MDBs pathogenesis on DDC-induced MDBs mouse model by single-nucleus RNA sequencing (snRNA-seq).
View Article and Find Full Text PDFHepatic lipid accumulation, or Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is a significant risk factor for liver cancer. Despite the rising incidence of MASLD, the underlying mechanisms of steatosis and lipotoxicity remain poorly understood. Interestingly, lipid accumulation also occurs during fasting, driven by the mobilization of adipose tissue-derived fatty acids into the liver.
View Article and Find Full Text PDFTissue Determinants of Antiviral Immunity in the Liver.
Z Gastroenterol
January 2025
Institute of Molecular Immunology, School of Life Science, Technical University of Munich, Munich, Germany.
The liver is an organ bearing important metabolic and immune functions. Hepatocytes are the main metabolically active cells of the liver and are the target of infection by hepatotropic viruses. Virus-specific CD8 T cells are essential for the control of hepatocyte infection with hepatotropic viruses but may be subject to local regulation of their effector function.
View Article and Find Full Text PDFDistribution of the p66Shc Adaptor Protein Among Mitochondrial and Mitochondria-Associated Membranes Fractions in Normal and Oxidative Stress Conditions.
Int J Mol Sci
November 2024
Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Article Synopsis
- - p66Shc is an adaptor protein crucial for regulating cellular functions including signaling pathways, mitochondrial activity, and the production of reactive oxygen species (ROS), with its location shifting to mitochondria under oxidative stress.
- - The protein is also implicated in mitochondria-associated membranes (MAM), which play a role in key cellular processes like calcium balance, apoptosis (cell death), and autophagy (cell cleaning), suggesting p66Shc's involvement in determining cell fate.
- - This study investigates the distribution of p66Shc in different parts of mouse liver tissue and HepG2 cells, demonstrating a significant presence of p66Shc in MAM under both normal and oxidative stress conditions.
Augmenter of Liver Regeneration (ALR) Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic Steatosis.
Cell Mol Gastroenterol Hepatol
December 2024
Department of Cell Biology and the Municipal Key Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing, People's Republic of China. Electronic address:
Background & Aims: Crotonylation (Kcr), a newly identified post-translation modification (PTM), has been confirmed to be involved in diverse biological processes and human diseases as well. Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a serious threat to people's health. Augmenter of liver regeneration (ALR) is an important liver regulatory protein, and the insufficiency of ALR expression is reported to accelerate liver steatosis progression to liver fibrosis or even hepatic carcinoma (HCC).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!