Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000149496 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
DMT1 (NRAMP2/DCT1) genetic variability and resistance to recombinant human erythropoietin therapy in chronic kidney disease patients under haemodialysis.
Acta Haematol
November 2008
Faculdade de Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto, Portugal.
Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life.
Biochem Cell Biol
June 2006
Department of Nutrition, University of California, 3217C Meyer Hall, One Shields Ave, Davis, CA 95616, USA.
It has been proposed that lactoferrin receptor (LfR) may be involved in intestinal iron transport during early life. However, it is known that iron homeostasis is regulated by divalent metal transporter 1 (DMT1; Nramp2/DCT1) in the adult small intestine. To address the hypothesis that LfR may play a role as an alternative iron transport pathway during early life, we used immunohistochemistry (IHC) to examine the localization of mouse LfR (mLfR) and DMT1.
View Article and Find Full Text PDFMolecular evidence for the role of a ferric reductase in iron transport.
Biochem Soc Trans
August 2002
Division of Life Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK.
Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.
View Article and Find Full Text PDFExpression of the iron transporter DMT1 in kidney from normal and anemic mk mice.
Kidney Int
July 2002
Department of Biochemistry, McGill University, 3655 Drummond, Montreal, Quebec, Canada H3G 1Y6.
Background: DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues. DMT1 mRNA and protein expression has been detected in rat and mouse kidney, but its role at that site remains to be clarified.
Methods: Immunoblotting and immunohistochemistry with specific affinity purified anti-DMT1 polyclonal antibodies were used to study expression and localization of DMT1 in mouse kidney.
Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice.
Blood
December 2001
Department of Biochemistry, McGill University, Montreal, QC, Canada.
Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues. Iron transport and expression of the 2 isoforms of DMT1 was studied in erythroid cells that consume large quantities of iron for biosynthesis of hemoglobin. In mk/mk mice that express a loss-of-function mutant variant of DMT1, reticulocytes have a decreased cellular iron uptake and iron incorporation into heme.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!