AI Article Synopsis
- - The study aimed to examine the structure of fibroblasts, collagen, and elastic fibers in vocal fold polyps compared to normal tissues using advanced microscopy techniques.
- - Results showed an increase in activated fibroblasts and signs of inflammation in polyps, indicating an active metabolism of the extracellular matrix.
- - The findings suggest that the irregular arrangement of collagen and elastic fibers in polyps could lead to changes in their function, affecting vocal fold health.
Article Abstract
Objective: The purpose of this study was to observe the ultrastructure of the fibroblasts, collagen and elastic fibers in vocal fold polyps.
Methods: Ten vocal fold polyps and 3 normal vocal fold specimens obtained from total laryngectomy were studied by means of transmission electron microscope and scanning electron microscope.
Results: The result showed that in vocal fold polyps, the quantity of fibroblasts increased and there were abundant organelles, suggesting that the fibroblast were in the status of activation. As the main cell to produce lamina propria extracellular matrix, the representation suggested that the extracellular matrix metabolism was active. Leucocytes soakage was observed, suggesting that the inflammation may play a role in the lesion. It was found by scanning electron microscopy that in case of lesions, collagen fibers and elastic fibers arrayed irregularly.
Conclusions: Under pathologic circumstance, fibroblasts, collagen and elastic fibers altered in morphology, which possibly induced the functional alteration.
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