Endometriosis can be a highly incapacitating disorder. The only effective treatment used to be surgery (increasingly by laparoscopy), and hormone therapy was solely used as an adjuvant. Today, thanks in particular to progress in sonography and MRI, and to the growing realization of the frequent role of psychological factors, medical treatment is becoming more commonplace. Drug therapy must be envisaged in the very long term, however, because its efficacy disappears on treatment cessation.
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Adv Exp Med Biol
October 2024
Department of Stem Cells & Regenerative Medicine, D.Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, India.
The human endometrium, the innermost lining of the uterus, is the anatomic prerequisite for pregnancy. It is the only dynamic tissue that undergoes more than 400 cycles of regeneration throughout the reproductive life of women. Key to this function are endometrial stem cells as well as cell adhesion molecules.
View Article and Find Full Text PDFInt J Reprod Biomed
May 2024
Department of Basic Medical Sciences, Faculty of Dentistry, Zarqa University, Zarqa City, Jordan.
Front Pharmacol
May 2024
College of Integrated Chinese and Western Medicine, Jining Medical University, Jining, Shandong Province, China.
Adiponectin is a pleiotropic cytokine predominantly derived from adipose tissue. In addition to its role in regulating energy metabolism, adiponectin may also be related to estrogen-dependent diseases, and many studies have confirmed its involvement in mediating diverse biological processes, including apoptosis, autophagy, inflammation, angiogenesis, and fibrosis, all of which are related to the pathogenesis of endometriosis. Although many researchers have reported low levels of adiponectin in patients with endometriosis and suggested that it may serve as a protective factor against the development of the disease.
View Article and Find Full Text PDFCell Signal
August 2024
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, PR China. Electronic address:
Despite decades of research, endometriosis remains a mysterious gynecological disease with unknown etiology and pathogenesis. Krüppel-like Factor 6 (KLF6), a transcription factor, has a wide expression profile and regulates a variety of biological processes. Here, we investigated the expression and function of KLF6 and its possible regulatory mechanisms in endometriosis.
View Article and Find Full Text PDFCell Commun Signal
January 2024
Department of Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, 419# Fangxie Road, Shanghai, 200011, China.
Background: As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions. Succinate accumulation in the cytoplasm is commonly associated with hypoxia in the microenvironment and immune cell activation. Extracellular succinate released into the microenvironment is considered an inflammatory alarm that can be sensed by its membrane receptor SUCNR1, which boosts proinflammatory responses and acts akin to classical hormones and cytokines.
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