AI Article Synopsis
- Impaired microcirculation in chronic complex regional pain syndrome (CRPS) leads to increased vasoconstriction, tissue hypoxia, and metabolic issues in the limbs, primarily due to endothelial dysfunction.
- The study analyzed skin tissues from amputated limbs of two CRPS patients, focusing on the distribution of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) along with vascular density marked by CD31.
- Results indicated an increase in endothelial cell migration and eNOS activity in the distal areas of the skin, suggesting that endothelial dysfunction significantly contributes to chronic CRPS.
Article Abstract
Background And Objectives: Impaired microcirculation during the chronic stage of complex regional pain syndrome (CRPS) is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb. Endothelial dysfunction is suggested to be the main cause of diminished blood flow. The aim of this study was to examine the distribution of endothelial nitric oxide synthase (eNOS) and endothelin-1(ET-1) relative to vascular density represented by the endothelial marker CD31-immunoreactivity in the skin tissue of patients with chronic CRPS.
Methods: We performed immunohistochemical staining on sections of skin specimens obtained from the amputated limbs (one arm and one leg) of two patients with CRPS.
Results: In comparison to proximal specimens we found an increased number of migrated endothelial cells as well as an increase of eNOS activity in distal dermis specimens.
Conclusions: We found indications that endothelial dysfunction plays a role in chronic CRPS.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475604 | PMC |
| http://dx.doi.org/10.1155/2008/680981 | DOI Listing |
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