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Technical advances in laboratory diagnosis of bloodstream infections.
Expert Rev Mol Diagn
January 2025
Hebei Provincial Center for Clinical Laboratories, Shijiazhuang, China, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People's Republic of China.
Introduction: Rapid and accurate laboratory diagnosis is essential for the effective treatment of bloodstream infection (BSI).
Areas Covered: This review aims to address novel and traditional approaches that exhibit different performance characteristics in the diagnosis of BSI. In particular, the authors will discuss the pros and cons of the blood culture-based phenotypic methods, nucleic acid-targeted molecular methods, and host response-targeted biomarker detection in the diagnosis of BSI.
Pros and cons of surgical versus conservative management for head and neck paraganglioma: a real-world data analysis.
Endocrine
January 2025
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy.
Purpose: To compare functional deficits associated to surgery with those caused by the growth of the head and neck paragangliomas (HNPGLs).
Methods: 72 patients with HNPGLs were included. Patients were divided in group A (49 patients undergoing surgery) and group B (23 patients following a wait and see approach).
Immunoblot evaluation of rubella humoral immunity in Portuguese women with negative or low-positive rubella IgG.
Diagn Microbiol Infect Dis
January 2025
CHRC, NOVA Medical School Faculdade de Ciências Médicas, NMS FCM, Universidade NOVA de Lisboa; Campo dos Mártires da Pátria 130, 1169-056 Lisboa, Portugal.
Despite its low incidence in Europe, rubella's immune status is still routinely assessed using commercial immunoassays. However, some discrepancies have been observed between these tests and the Immunoblot. The main objective of this study is to evaluate, by a commercial immunoblot, the immune status of a female population that had previously presented negative, low-positive, or equivocal rubella IgG with a commercial immunoassay.
View Article and Find Full Text PDFComparison of the Modified CTOD Measurement Method with the Double Clip Gauge Method in a Compact Tension Specimen.
Materials (Basel)
January 2025
Smart Forming Process Group, Korea Institute of Industrial Technology, Ulsan 44776, Republic of Korea.
For allowable defect analyses, the fracture toughness of materials needs to be accurately predicted. In this regard, a lower fluctuation of fracture toughness can lead to reduction in safety and economic risks. Crack tip opening displacement (CTOD), which is the representative parameter for fracture toughness, can be measured by various methods, such as the δ5, the J-conversion method, the single clip gauge method, and the double clip gauge method.
View Article and Find Full Text PDFHarnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings.
Antibiotics (Basel)
January 2025
School of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming's warning about the misuse of antibiotics leading to resistant microbes. With a dwindling arsenal of effective antibiotics, it is imperative to concentrate on alternative antimicrobial strategies. Previous studies have not comprehensively discussed the advantages and limitations of various strategies, including bacteriophage therapy, probiotics, immunotherapies, photodynamic therapy, essential oils, nanoparticles and antimicrobial peptides (AMPs) within a single review.
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