AI Article Synopsis
- Previous studies indicate that the sire plays a crucial role in the immune response of broiler chickens, influencing leukocyte function and cytokine profiles.
- The research aims to select sires with elevated levels of pro-inflammatory cytokines (IL-1beta, IL-6) and chemokines (CXCLi2, CCLi2) to enhance the immune traits in their progeny.
- After analyzing 119 sires, it was found that offspring from high cytokine sires displayed significantly higher levels of pro-inflammatory markers compared to those from low sires, demonstrating the effectiveness of the selection approach.
Article Abstract
Previous studies using F1 reciprocal crosses and two parental lines of broilers show the sire is instrumental in determining the in vitro leukocyte function and cytokine/chemokine profile. Since the innate immune response is the primary means young chickens have to protect themselves, we hypothesize utilizing a novel genomics approach to select sires based on an elevated pro-inflammatory cytokine and chemokine profile. By identifying sires with increased pro-inflammatory cytokine (interleukin [IL]-1beta and IL-6) and chemokine (CXCLi2 and CCLi2) mRNA expression levels, we expect the progeny will also have elevated profiles. We characterized the pro-inflammatory cytokine and chemokine profile of 119 sires using quantitative real-time RT-PCR (qRT-PCR) and identified two populations with inherently high and low mRNA expression levels of IL-1beta, IL-6, CXCLi2, and CCLi2. Select high and low sires were then used to produce progeny for the second phase of the trial. Blood samples were collected from 214 progeny and the cytokine and chemokine mRNA expression levels determined. Progeny from high sires had significantly (P
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http://dx.doi.org/10.1016/j.vetimm.2008.06.005 DOI Listing Publication Analysis
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