Delirium is a common event in geriatric hospitalized patients. A prospective study was performed in order to characterize predictors, features and outcome in an acute geriatric care unit in a general hospital in Israel. The tools used to detect delirium were the Confusion Assessment Method (CAM) and the Delirium Rating Scale (DRS), supported by clinical observation by an experienced geriatrician. Results showed an occurrence of 18%; risk factors were polypharmacy and poor nutritional status. Age, education, ethnic origin, pre-morbid cognition and ADL status did not show any statistical correlation with the occurrence of delirium. Delirious patients experienced longer hospital stays, more complications, high mortality rate, cognitive and functional decline. It is very difficult to prove the correlation between reduction of brain reserve and appearance of delirium, but as we have observed in other systems (cardiovascular, renal, etc.), it seems reasonable to presume that the same mechanism is involved in cognitive function. Our conclusions are that the diagnosis of delirium may be misleading by a psychiatric overwhelming presentation, and should be considered not as a transient event, but as a marker for cognitive and functional decline in the future, and therefore these patients should be looked after once discharged.
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http://dx.doi.org/10.1016/s0167-4943(98)00124-1 | DOI Listing |
Alzheimers Dement
December 2024
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.
Clin Chim Acta
December 2024
Southwest Finland Wellbeing Services County, Turku University Hospital Services, Geriatric Medicine, 20521 Turku, Finland; Faculty of Medicine, Department of Clinical Medicine, Unit of Geriatric Medicine, University of Turku and Turku University Hospital, 20700 Turku, Finland.
Background: Cardiac troponin T (cTnT) and N-terminal B-type natriuretic propeptide (proBNP) are mainly used as biomarkers to diagnose specific conditions of the heart, but they also have predictive ability. Our aim was to study their associations with cardiovascular and all-cause mortality in an older population in non-acute conditions.
Methods: A population-based study with a ten-year follow-up.
Geriatr Nurs
December 2024
Department of Geriatrics, Peking University Third Hospital, Beijing, People's Republic of China. Electronic address:
Objective: To assess muscle loss via ultrasound in the elderly and its link to clinical outcomes and risk factors.
Methods: This retrospective cohort study assessed muscle loss in hospitalized elderly via ultrasound, comparing bilateral anterior thigh thickness (BATT) at admission and after seven days, exploring its relation to hospital-acquired complications (HACs).
Results: In 86 patients (mean age 83.
J Pain Palliat Care Pharmacother
December 2024
The Department of Acute Geriatric Medicine, Soroka University Medical Centre, Be'er Sheva, Israel.
Serotonin toxicity (ST) is a preventable, life-threatening condition caused by serotonergic agents. It typically arises from combined drug use that affects serotonin's release and metabolism. While often presenting with mild symptoms that may be overlooked or misdiagnosed, severe toxicity is associated with significant mortality.
View Article and Find Full Text PDFClin Nutr
December 2024
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy; Geriatric Clinic, Maggiore University Hospital, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Trieste, Italy; School of Dietetics, University of Trieste - Pordenone branch, Pordenone, Italy.
Background & Aims: Malnutrition and cognitive impairment are among the major contributors to frailty, that significantly increases the risk of mortality of older hospitalized patients. Multidimensional frailty assessment tools, such as the multidimensional prognostic index-MPI, a tool based on a standard comprehensive geriatric assessment (CGA), have proven valuable for predicting adverse outcomes, including mortality of older adults following acute illness but its application in everyday clinical practice is limited. We hypothesized that removing parameters not closely associated with mortality and sorting the patient population according to the presence or not of cognitive impairment with possible integration of common laboratory markers, could provide a simplified approach that could improve practicability in all settings with at least comparable 1-year mortality predictive value.
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