AI Article Synopsis
- Most research on Aspergillus infections has focused on A. fumigatus, the most common species, making it crucial to compare it with A. flavus to understand their pathogenicity.
- Studies suggest that A. flavus may be more virulent than A. fumigatus, but current experiments often fail to accurately reflect real-life invasive aspergillosis scenarios.
- A. flavus is known to cause fungal sinusitis and skin infections, and its larger spores might explain its preference for upper respiratory tract deposits, highlighting the need for more research on A. flavus infections.
Article Abstract
Most of the information available about Aspergillus infections has originated from the study of A. fumigatus, the most frequent species in the genus. This review aims to compare the pathogenicity and clinical aspects of Aspergillosis caused by A. fumigatus an A. flavus. Experimental data suggests that A. flavus is more virulent than A. fumigatus. However, these were mostly models of disseminated Aspergillus infection which do not properly mimic the physiopathology of invasive aspergillosis, a condition that is usually acquired by inhalation. In addition, no conclusive virulence factor has been identified for Aspergillus species. A. flavus is a common cause of fungal sinusitis and cutaneous infections. Chronic conditions such as chronic cavitary pulmonary aspergillosis and sinuses fungal balls have rarely been associated with A. flavus. The bigger size of A. flavus spores, in comparison to those of A. fumigatus spores, may favour their deposit in the upper respiratory tract. Differences between these species justify the need for a better understanding of A. flavus infections.
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| http://dx.doi.org/10.1080/13693780802247702 | DOI Listing |
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