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Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest. | LitMetric
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Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.

Yasuhiro Kojima Toshiaki Sunazuka Kenichiro Nagai Khachatur Julfakyan Takashi Fukuda Hiroshi Tomoda Satoshi Omura

J Antibiot (Tokyo)

Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Published: May 2008

Total synthesis of a fungal cyclic peptide, malformin C, recently rediscovered as a G2 checkpoint inhibitor was completed. Our synthesis involved a convergent approach with respect to a linear pentapeptide, cyclization, and oxidative disulfide formation.

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 Source
http://dx.doi.org/10.1038/ja.2008.42DOI Listing

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